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Proceedings Paper

Biosensing with integrated CMOS nanopores
Author(s): Ashfaque Uddin; Sukru Yemenicioglu; Chin-Hsuan Chen; Ellie Corgliano; Kaveh Milaninia; Fan Xia; Kevin Plaxco; Luke Theogarajan
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Paper Abstract

This paper outlines our recent efforts in using solid-state nanopores as a biosensing platform. Traditionally biosensors concentrate mainly on the detection platform and not on signal processing. This decoupling can lead to inferior sensors and is exacerbated in nanoscale devices, where device noise is large and large dynamic range is required. This paper outlines a novel platform that integrates the nano, micro and macroscales in a closely coupled manner that mitigates many of these problems. We discuss our initial results of DNA translocation through the nanopore. We also briefly discuss the use of molecular recognition properties of aptamers with the versatility of the nanopore detector to design a new class of biosensors in a CMOS compatible platform.

Paper Details

Date Published: 10 October 2012
PDF: 6 pages
Proc. SPIE 8460, Biosensing and Nanomedicine V, 846010 (10 October 2012); doi: 10.1117/12.945553
Show Author Affiliations
Ashfaque Uddin, Univ. of California, Santa Barbara (United States)
Sukru Yemenicioglu, Univ. of California, Santa Barbara (United States)
Chin-Hsuan Chen, Univ. of California, Santa Barbara (United States)
Ellie Corgliano, Univ. of California, Santa Barbara (United States)
Kaveh Milaninia, Univ. of California, Santa Barbara (United States)
Fan Xia, Univ. of California, Santa Barbara (United States)
Kevin Plaxco, Univ. of California, Santa Barbara (United States)
Luke Theogarajan, Univ. of California, Santa Barbara (United States)


Published in SPIE Proceedings Vol. 8460:
Biosensing and Nanomedicine V
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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