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Proceedings Paper

Constrained Tryptophan Has A Monoexponential Decay
Author(s): Melissa C Sattler; William R Cherry; Mary D Barkley
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Paper Abstract

The fluorescence decay of tryptophan is complex. Various models have been proposed to account for the multiexponential decay, including ground-state rotamers, excited-state proton transfer, and lifetime distributions.1-4 In order to test the rotamer model, we are studying a series of tryptophan derivatives in which rotation about the Ca-CB and CB-Cy, bonds is constrained. The ground-state conformations are determined by X-ray diffraction, molecular and 1H NMR. Or preliminary results for a tryptophan derivative with the a-amino group incorporated in a six-member ring are described below.

Paper Details

Date Published: 24 June 1988
PDF: 2 pages
Proc. SPIE 0909, Time-Resolved Laser Spectroscopy in Biochemistry, (24 June 1988); doi: 10.1117/12.945389
Show Author Affiliations
Melissa C Sattler, Louisiana State University (United States)
William R Cherry, Louisiana State University (United States)
Mary D Barkley, Louisiana State University (United States)

Published in SPIE Proceedings Vol. 0909:
Time-Resolved Laser Spectroscopy in Biochemistry
Joseph R. Lakowicz, Editor(s)

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