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Proceedings Paper

New Photosensitizers For Photodynamic Therapy Of Transplantable And Spontaneous Animal Tumors
Author(s): Steven H Selnan; Andrew J Milligan; Ahmed El -Taki; Rick W Keck; Greta M Garbo; Martha Kreimer-Birnbaum; Alan R Morgan
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Paper Abstract

Metallopurpurins, metalloderivatives of a group of new photosensitizers called purpurins, have previously been reported to be excellent photosensitizers for the photodynamic treatment of experimental transplantable bladder tumors. Work in our laboratory has demonstrated that a dose of 1.0 mg/kg, of the metallopurpurin Sn etiopurpurin (II) dichloride, SnET2, is effective in producing significant tumor regression and cure in an experimental transplantable bladder tumor'. To confirm these findings a second tumor model using the transplantable R3327-AT prostatic adenocarcinoma was examined. In this model 1.0 mg/kg of SnET2 was ineffective in causing tumor regression. At 2.5 mg/kg there was obvious tumor regression although the results did not reach statistical significance. However, at this dose, 2/5 animals were free of tumor when examined histologically twelve days after treatment. In a set of related experiments blood flow measure-ments to this tumor were made using the radioactive microsphere technique. As with other photosensitizers, blood flow was reduced using metallopurpurin-PDT. In order to further establish the photodynamic activity of this drug, spontaneous canine tumors were treated with varying doses of light and drug. All animals tolerated the drug well. A photodynamic effect was apparent in all treated animals. These studies suggest that the netallopurpurin SnET2 may be an alter-native to the currently available drugs used for PDT.

Paper Details

Date Published: 3 June 1988
PDF: 4 pages
Proc. SPIE 0908, Laser Interaction with Tissue, (3 June 1988); doi: 10.1117/12.945352
Show Author Affiliations
Steven H Selnan, Medical College of Ohio (United States)
Andrew J Milligan, Medical College of Ohio (United States)
Ahmed El -Taki, Medical College of Ohio (United States)
Rick W Keck, Medical College of Ohio (United States)
Greta M Garbo, Medical College of Ohio (United States)
Martha Kreimer-Birnbaum, University of Toledo (United States)
Alan R Morgan, University of Toledo (United States)

Published in SPIE Proceedings Vol. 0908:
Laser Interaction with Tissue
Michael W. Berns, Editor(s)

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