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Proceedings Paper

Review Of Fluorescence Diagnosis Using Porphyrins
Author(s): A E Profio
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Paper Abstract

Tumors can be detected by their increased fluorescence compared to surrounding tissue, several hours after injection of a fluorescent, tumor-localizing compound such as dihematoporphyrin ether. The fluorescence is observed by either a nonimaging photodetector, with appropriate filters, or by an imaging optical system (usually employing an image intensifier because the fluorescence is weak). Excitation is best carried out with a laser, but a filtered arc lamp may be suitable. Instruments differ in the methods of excitation, detection, reduction of background from native fluorescence of tissues, and provision for a whitelight - illuminated reflectance image or other means for guiding and identification of anatomical landmarks. Carcinoma in situ has been detected by a number of these instruments.

Paper Details

Date Published: 15 June 1988
PDF: 7 pages
Proc. SPIE 0907, Laser Surgery: Characterization and Therapeutics, (15 June 1988); doi: 10.1117/12.945332
Show Author Affiliations
A E Profio, University of California (United States)


Published in SPIE Proceedings Vol. 0907:
Laser Surgery: Characterization and Therapeutics
Kazuhiko Atsumi; Stephen N. Joffe, Editor(s)

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