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Proceedings Paper

Pulsed Versus Continuous-Wave 680 Nm Laser Light In Photosensitization By Chloroaluminum Phthalocyanine Tetrasulfonate
Author(s): E. Ben-Hur; H. C. Newman; S. W. Crane; I. RosenthaI
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Paper Abstract

The efficiency of pulsed (4.5 kHz) and continuous-wave (CW) laser light (680 nm) in causing phototoxicity with chloroaluminum phthalocyanine tetrasulfonate (AIPCS) was studied using colony-forming ability of Chinese hamster fibroblast cells as an endpoint. CW light was nearly 5-fold more effective than pulsed light. The difference is ascribed to the 104 higher peak power density during pulsed illumination. Two explanations are advanced to explain this result: (a) the oxygen content becomes the limiting factor for the photodynamic reaction; (b) the complete conversion of AIPCS molecules to excited states during the pulse results in underutilization of the available photons. Experimental approaches to test these hypotheses are suggested.

Paper Details

Date Published: 19 February 1988
PDF: 4 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942704
Show Author Affiliations
E. Ben-Hur, Nuclear Research Center (Israel)
H. C. Newman, North Carolina State University School (United States)
S. W. Crane, North Carolina State University School (United States)
I. RosenthaI, A.R.O. (Israel)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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