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Proceedings Paper

A Role For Photodynamic Therapy In Autologous Bone Marrow Transplantation
Author(s): Fritz Sieber
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Paper Abstract

Simultaneous exposure to the amphipathic fluorescent dye merocyanine 540 (MC 540) and light of a suitable wavelength rapidly kills leukemia, lymphoma, and neuroblastoma cells but spares normal pluripotent hematopoietic stem cells. Tests in several preclinical models and early results of a phase I clinical trial suggest that MC 540-mediated photosensitization may be useful for the extracorporeal purging of autologous remission bone marrow grafts.

Paper Details

Date Published: 19 February 1988
PDF: 6 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942703
Show Author Affiliations
Fritz Sieber, Medical College of Wisconsin (United States)


Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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