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Proceedings Paper

Predicting In Vivo Phototoxicity In The Lens Using In Vitro And Photophysical Studies
Author(s): Joan E. Roberts; James Dillon
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Paper Abstract

Photodynamic Therapy is an effective treatment of malignant tumors. However the Rophyrin dyes Erggently used are associated with phototoxic effects in the skin and the eye Numerous new dyes are being developed which will hopefully combine effectiveness in treating tumors with fewer phototoxic side effects. We report here a method to assess the relative phototxicity of porphyrins in lenticular tissues that involves both in vitro, photophysical and in vivo studies. This methodology can be used to screen for potential phototoxic side effects of new photosensitizing drugs as they are being developed and to develop means by which that damage may be prevented.

Paper Details

Date Published: 19 February 1988
PDF: 7 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942701
Show Author Affiliations
Joan E. Roberts, Fordham University (United States)
James Dillon, Columbia University (United States)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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