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Proceedings Paper

Mitochondria In Cancer Cells As Targets Of Photodynamic Therapy
Author(s): Russell Hilf; Scott L. Gibson; Richard S. Murant; Toni L. Ceckler; Robert G. Bryant
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Paper Abstract

Encouraging results are being reported in treatment of cancer by photodynamic therapy, consisting of the administration of hematoporphyrin photosensitizers and subsequent illumination of the neoplastic lesion with visible light. Studies in our laboratory have peen directed towards defining cellular sites of action of these photosensitizers. Results obtained using a rodent mammary carcinoma in vitro and in vivo indicate that an important target of tumor photosensitization is the mitochondrion, effects that are manifested by inhibition of enzymes involved in electron transport and oxidative phosphorylation. These events in turn lead to a significant reduction in cellular ATP, which we suggest represents an early and important mechanism that contributes to the ensuing tumor cytotoxicity. Optimization of this mechanism could provide improved efficacy of treatment.

Paper Details

Date Published: 19 February 1988
PDF: 9 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942683
Show Author Affiliations
Russell Hilf, The University of Rochester (United States)
Scott L. Gibson, The University of Rochester (United States)
Richard S. Murant, The University of Rochester (United States)
Toni L. Ceckler, The University of Rochester (United States)
Robert G. Bryant, The University of Rochester (United States)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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