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Proceedings Paper

Holographic Measurement Of Particulate Contamination In Sealed Sterile Containers
Author(s): John C. Zeiss; Julius Z. Knapp; Joe S. Crane; Paul Dunn; Brian J . Thompson
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Paper Abstract

The presence of particulates, in injectable: solutions, can be medically hazardous depending on their size and shape. Hence, a. mandatory particulate inspection is performed prior to the release of any injectable drug. However, the determination of realistic quality limits, has been hampered by the absence of any physical non-destructive, measurement or comparison technique. This paper describes a far-field holographic' method for the measurement of particulate, contamination in sealed sterile containers. This application of holography provides to the pharmaceutical industry for the first. time, a non-destructive technique to inspect production containers and to classify the size and quantity of contaminants.

Paper Details

Date Published: 7 July 1983
PDF: 8 pages
Proc. SPIE 0353, Industrial and Commercial Applications of Holography, (7 July 1983); doi: 10.1117/12.933957
Show Author Affiliations
John C. Zeiss, Schering Corporation (United States)
Julius Z. Knapp, Schering Corporation (United States)
Joe S. Crane, University of Rochester (United States)
Paul Dunn, University of Rochester (United States)
Brian J . Thompson, University of Rochester (United States)


Published in SPIE Proceedings Vol. 0353:
Industrial and Commercial Applications of Holography
Milton Chang, Editor(s)

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