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Proceedings Paper

Protein-Polymer Interaction Studied By Fourier Transform Infrared (FTIR)
Author(s): R. M. Gendreau; S. Winters; L. Lee; R. I. Leininger; R. J. Jakobsen
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Paper Abstract

Research at our labs concerning studies of protein adsorption onto surfaces was just beginning when we presented a paper at the 1977 International FT-IR Meeting. Since that time, a quantum leap has occurred in our ability to study protein adsorption from flowing protein solutions (including whole blood) onto various surfaces. The work we will present involves using ATR in conjunction with FT-IR to study adsorption of blood proteins in real time as it adsorbs onto polymer coated ATR crystals. Through multiple subtraction and other data reduction techniques, meaningful data concerning how proteins interact with surfaces and with each other is obtained. Polymers have been found to influence protein adsorption patterns, and FT-IR is being used to study these effects. This type of study is assisting in the development of theory concerning the fabrication of surfaces with enhanced biocompatibility.

Paper Details

Date Published: 29 October 1981
PDF: 1 pages
Proc. SPIE 0289, 1981 Intl Conf on Fourier Transform Infrared Spectroscopy, (29 October 1981); doi: 10.1117/12.932163
Show Author Affiliations
R. M. Gendreau, Battelle Columbus Laboratories (United States)
S. Winters, Battelle Columbus Laboratories (United States)
L. Lee, Battelle Columbus Laboratories (United States)
R. I. Leininger, Battelle Columbus Laboratories (United States)
R. J. Jakobsen, Battelle Columbus Laboratories (United States)

Published in SPIE Proceedings Vol. 0289:
1981 Intl Conf on Fourier Transform Infrared Spectroscopy
Hajime Sakai, Editor(s)

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