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Proceedings Paper

Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles
Author(s): Margarita Hernández; Gonzalo Recio; Paz Sevilla; Vicente Torres-Costa; José V. García-Ramos; Concepción Domingo; Raúl J. J. Martín-Palma
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Paper Abstract

A study of the fluorescence and Raman spectra of a new and complex drug delivery system formed by emodin adsorbed on silver nanoparticles embedded into a matrix of porous silicon is here reported. Several experimental methods of inclusion of the drug-silver set inside the pores, without previous functionalization of porous silicon, have been tested in order to optimize the conditions for the fluorescence detection of emodin. In this sense, we have also added bovine serum albumin to the system, finding that the presence of the protein enhances the fluores-cence signal from emodin.

Paper Details

Date Published: 10 October 2012
PDF: 5 pages
Proc. SPIE 8465, Nanostructured Thin Films V, 846509 (10 October 2012); doi: 10.1117/12.931117
Show Author Affiliations
Margarita Hernández, Consejo Superior de Investigaciones Científicas (Spain)
Gonzalo Recio, Univ. Autónoma de Madrid (Spain)
Paz Sevilla, Consejo Superior de Investigaciones Científicas (Spain)
Univ. Complutense de Madrid (Spain)
Vicente Torres-Costa, Univ. Autónoma de Madrid (Spain)
José V. García-Ramos, Consejo Superior de Investigaciones Científicas (Spain)
Concepción Domingo, Consejo Superior de Investigaciones Científicas (Spain)
Raúl J. J. Martín-Palma, Univ. Autónoma de Madrid (Spain)

Published in SPIE Proceedings Vol. 8465:
Nanostructured Thin Films V
Tom G. Mackay; Yi-Jun Jen; Raúl J. Martín-Palma, Editor(s)

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