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Proceedings Paper

Photothermal nanoblade for single cell surgery and cargo delivery
Author(s): Pei-Yu Chiou; Ting-Hsiang Wu; Michael A Teitell
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Paper Abstract

This work presents a novel photothermal nanoblade that utilizes metallic nanostructures to light energy from short laser pulses to generate highly localized and shaped explosive cavitation bubbles which enables rapid cut of a lightly contacting cell membrane of a mammalian cell. Photothermal nanoblade can generate micrometer-sized membrane access ports for delivering large size cargo with high efficiency and high cell viability. Biologic and inanimate cargo over 3-orders of magnitude in size including DNA, RNA, 200 nm polystyrene beads, to 2 μm bacteria have also been successfully delivered into multiple mammalian cell types.

Paper Details

Date Published: 10 October 2012
PDF: 7 pages
Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600Q (10 October 2012); doi: 10.1117/12.930754
Show Author Affiliations
Pei-Yu Chiou, Univ. of California, Los Angeles (United States)
Ting-Hsiang Wu, Univ. of California, Los Angeles (United States)
Michael A Teitell, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 8460:
Biosensing and Nanomedicine V
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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