Share Email Print
cover

Proceedings Paper

Measurement of PLGA-NP interaction with a single smooth muscle cell using optical tweezers
Author(s): Ling Gu; Argha Mondal; Homa Homayoni; Kytai Nguyen; Samarendra Mohanty
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

For intervention of cardiovascular diseases, biodegradable and biocompatible, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) are emerging as agents of choice for controlled and targeted drug delivery. Therefore development of PLGA-NP with optimal physico-chemical properties will allow efficient binding and thus delivery of drug to targeted cells under various patho-physiological conditions. The force kinetics and its dependence on size of the NPs will be crucial for designing the NPs. Since optical tweezers allow non-contact, highly sensitive force measurement with high spatial and temporal resolution, we utilized it for studying interaction forces between magnetic PLGA nanoparticles with smooth muscle cells (SMC). In order to investigate effect of size, interaction force for 200 to 1100nm PLGA NP was measured. For similar interaction duration, the force was found to be higher with increase in size. The rupture force was found to depend on time of interaction of SMC with NPs.

Paper Details

Date Published: 10 October 2012
PDF: 6 pages
Proc. SPIE 8460, Biosensing and Nanomedicine V, 846007 (10 October 2012); doi: 10.1117/12.930588
Show Author Affiliations
Ling Gu, The Univ. of Texas at Arlington (United States)
Argha Mondal, The Univ. of Texas at Arlington (United States)
Indian Institute of Science Education and Research (India)
Homa Homayoni, The Univ. of Texas at Arlington (United States)
Kytai Nguyen, The Univ. of Texas at Arlington (United States)
Samarendra Mohanty, The Univ. of Texas at Arlington (United States)


Published in SPIE Proceedings Vol. 8460:
Biosensing and Nanomedicine V
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

© SPIE. Terms of Use
Back to Top