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Proceedings Paper

Morphology of atherosclerotic coronary arteries
Author(s): Margaret N. Holme; Georg Schulz; Hans Deyhle; Simone Elke Hieber; Timm Weitkamp; Felix Beckmann; Julia Herzen; Johannes A. Lobrinus; Fabrizio Montecucco; François Mach; Andreas Zumbuehl; Till Saxer; Bert Müller
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Paper Abstract

Atherosclerosis, the narrowing of vessel diameter and build-up of plaques in coronary arteries, leads to an increase in the shear stresses present, which can be used as a physics-based trigger for targeted drug delivery. In order to develop appropriate nanometer-size containers, one has to know the morphology of the critical stenoses with isotropic micrometer resolution. Micro computed tomography in absorption and phase contrast mode provides the necessary spatial resolution and contrast. The present communication describes the pros and cons of the conventional and synchrotron radiation-based approaches in the visualization of diseased human and murine arteries. Using registered datasets, it also demonstrates that multi-modal imaging, including established histology, is even more powerful. The tomography data were evaluated with respect to cross-section, vessel radius and maximal constriction. The average cross-section of the diseased human artery (2.31 mm2) was almost an order of magnitude larger than the murine one (0.27 mm2), whereas the minimal radius differs only by a factor of two (0.51 mm versus 0.24 mm). The maximal constriction, however, was much larger for the human specimen (85% versus 49%). We could also show that a plastic model used for recent experiments in targeted drug delivery represents a very similar morphology, which is, for example, characterized by a maximal constriction of 82%. The tomography data build a sound basis for flow simulations, which allows for conclusions on shear stress distributions in stenosed blood vessels.

Paper Details

Date Published: 17 October 2012
PDF: 12 pages
Proc. SPIE 8506, Developments in X-Ray Tomography VIII, 850609 (17 October 2012); doi: 10.1117/12.930052
Show Author Affiliations
Margaret N. Holme, Basel Univ. Hospital (Switzerland)
Univ. of Fribourg (Switzerland)
Univ. Hospitals of Geneva (Switzerland)
Georg Schulz, Basel Univ. Hospital (Switzerland)
Hans Deyhle, Basel Univ. Hospital (Switzerland)
Simone Elke Hieber, Basel Univ. Hospital (Switzerland)
Timm Weitkamp, Synchrotron SOLEIL (France)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Julia Herzen, Helmholtz-Zentrum Geesthacht (Germany)
Johannes A. Lobrinus, Univ. Hospital of Geneva (Switzerland)
Fabrizio Montecucco, Univ. Hospitals of Geneva (Switzerland)
François Mach, Univ. Hospitals of Geneva (Switzerland)
Andreas Zumbuehl, Univ. of Fribourg (Switzerland)
Till Saxer, Univ. Hospitals of Geneva (Switzerland)
Bert Müller, Basel Univ. Hospital (Switzerland)

Published in SPIE Proceedings Vol. 8506:
Developments in X-Ray Tomography VIII
Stuart R. Stock, Editor(s)

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