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Proceedings Paper

Comparing the micro-vascular structure of cancerous and healthy tissues
Author(s): Bert Müller; Sabrina Lang; Felix Beckmann; Marco Dominietto; Markus Rudin; Irene Zanette; Timm Weitkamp; Alexander Rack; Simone Elke Hieber
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Paper Abstract

Basic research is required to develop more powerful approaches to prevent, diagnose, and above all to treat cancer, although the clever combination of surgery, chemical, pharmacological, and radiation therapies is well established. Our research activity concentrates on the quantification of the three-dimensional micro-morphology of vessel trees formed in cancerous and healthy tissues of a mouse model post mortem. While in several cases it is possible to extract the vessel tree from corrosion casts, phase contrast imaging modalities are needed for cancerous tissues with a significant amount of damaged vessel walls. Differences between cancerous and healthy tissues could be identified. The sum-of-angle metrics is found to be constant for vessel segments in cancerous and healthy tissues with lengths between 12 and 220 μm and corresponds to (0.62 ± 0.10) rad/μm.

Paper Details

Date Published: 17 October 2012
PDF: 10 pages
Proc. SPIE 8506, Developments in X-Ray Tomography VIII, 850607 (17 October 2012); doi: 10.1117/12.929941
Show Author Affiliations
Bert Müller, Basel Univ. Hospital (Switzerland)
Sabrina Lang, Basel Univ. Hospital (Switzerland)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Marco Dominietto, ETH Zurich (Switzerland)
Markus Rudin, ETH Zurich (Switzerland)
Irene Zanette, Technische Univ. München (Germany)
Timm Weitkamp, Synchrotron SOLEIL (France)
Alexander Rack, European Synchrotron Radiation Facility (France)
Simone Elke Hieber, Basel Univ. Hospital (Switzerland)


Published in SPIE Proceedings Vol. 8506:
Developments in X-Ray Tomography VIII
Stuart R. Stock, Editor(s)

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