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Proceedings Paper

Portable guided-mode resonance biosensor platform for point-of-care testing
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Paper Abstract

It represents a viable solution for the realization of a portable biosensor platform that could screen/diagnose acute myocardial infarction by measuring cardiac marker concentrations such as cardiac troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin (MYO) for application to u-health monitoring system. The portable biosensor platform introduced in this presentation has a more compact structure and a much higher measuring resolution than a conventional spectrometer system. Portable guided-mode resonance (GMR) biosensor platform was composed of a biosensor chip stage, an optical pick-up module, and a data display panel. Disposable plastic GMR biosensor chips with nano-grating patterns were fabricated by injection–molding. Whole blood filtration and label-free immunoassay were performed on these single chips, automatically. Optical pick-up module was fabricated by using the miniaturized bulk optics and the interconnecting optical fibers and a tunable VCSEL (vertical cavity surface emitting laser). The reflectance spectrum from the GMR biosensor was measured by the optical pick-up module. Cardiac markers in human serum with concentrations less than 0.1ng/mL were analyzed using a GMR biosensor. Analysis time was 30min, which is short enough to meet clinical requirements. Our results show that the GMR biosensor will be very useful in developing lowcost portable biosensors that can screen for cardiac diseases.

Paper Details

Date Published: 10 October 2012
PDF: 14 pages
Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600F (10 October 2012); doi: 10.1117/12.929457
Show Author Affiliations
Gun Yong Sung, Electronics and Telecommunications Research Institute (Korea, Republic of)
Wan-Joong Kim, Electronics and Telecommunications Research Institute (Korea, Republic of)
Hyunsung Ko, Electronics and Telecommunications Research Institute (Korea, Republic of)
Bong Kyu Kim, Electronics and Telecommunications Research Institute (Korea, Republic of)
Kyung-Hyun Kim, Electronics and Telecommunications Research Institute (Korea, Republic of)
Chul Huh, Electronics and Telecommunications Research Institute (Korea, Republic of)
Jongcheol Hong, Electronics and Telecommunications Research Institute (Korea, Republic of)


Published in SPIE Proceedings Vol. 8460:
Biosensing and Nanomedicine V
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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