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Proceedings Paper

Quantitative phase microscopy for the study of bone cells on multiple roughness surfaces
Author(s): Jesús González-Laprea; Ana H. Márquez; Karem Noris-Suarez; Rafael Escalona
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Paper Abstract

We present a phase shifting interferometry system for the study of the early adhesion process for osteoblast-like cells, through an interference microscope. Optical phase maps from the cells are obtained experimentally as a function of cell adhesion time. The process is carried out on surfaces of metallic materials relevant to the development of bone implants. The surfaces were subjected to various levels of mechanical polishing and their roughness was measured using the same experimental technique mentioned before. Morphological changes of the cell can be measured over their optical phase maps while the cell adhesion process is accomplished. The experimental technique shows a suitable feature as to the observed time scale, and also shows a high stockiness and precision for the determination of the optical phase.

Paper Details

Date Published: 13 September 2012
PDF: 9 pages
Proc. SPIE 8494, Interferometry XVI: Applications, 84940Q (13 September 2012); doi: 10.1117/12.928437
Show Author Affiliations
Jesús González-Laprea, Simón Bolívar Univ. (Venezuela)
Ana H. Márquez, Simón Bolívar Univ. (Venezuela)
Karem Noris-Suarez, Simón Bolívar Univ. (Venezuela)
Rafael Escalona, Simón Bolívar Univ. (Venezuela)

Published in SPIE Proceedings Vol. 8494:
Interferometry XVI: Applications
Cosme Furlong; Christophe Gorecki; Erik L. Novak, Editor(s)

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