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Proceedings Paper

Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates
Author(s): Chris Rowe Taitt; Tomasz Leski; David Stenger; Gary J. Vora; Brent House; Matilda Nicklasson; Guillermo Pimentel; Daniel V. Zurawski; Benjamin C. Kirkup; David Craft; Paige E. Waterman; Emil P. Lesho; Umaru Bangurae; Rashid Ansumana
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Paper Abstract

The prevalence of multidrug-resistant infections in personnel wounded in Iraq and Afghanistan has made it challenging for physicians to choose effective therapeutics in a timely fashion. To address the challenge of identifying the potential for drug resistance, we have developed the Antimicrobial Resistance Determinant Microarray (ARDM) to provide DNAbased analysis for over 250 resistance genes covering 12 classes of antibiotics. Over 70 drug-resistant bacteria from different geographic regions have been analyzed on ARDM, with significant differences in patterns of resistance identified: genes for resistance to sulfonamides, trimethoprim, chloramphenicol, rifampin, and macrolide-lincosamidesulfonamide drugs were more frequently identified in isolates from sources in Iraq/Afghanistan. Of particular concern was the presence of genes responsible for resistance to many of the last-resort antibiotics used to treat war traumaassociated infections.

Paper Details

Date Published: 5 May 2012
PDF: 10 pages
Proc. SPIE 8371, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX, 83710X (5 May 2012); doi: 10.1117/12.924569
Show Author Affiliations
Chris Rowe Taitt, U.S. Naval Research Lab. (United States)
Tomasz Leski, U.S. Naval Research Lab. (United States)
David Stenger, U.S. Naval Research Lab. (United States)
Gary J. Vora, U.S. Naval Research Lab. (United States)
Brent House, Naval Medical Research Unit-3 (Egypt)
Matilda Nicklasson, Naval Medical Research Unit-3 (Egypt)
Guillermo Pimentel, Naval Medical Research Ctr. (United States)
Daniel V. Zurawski, Walter Reed Army Institute of Research (United States)
Benjamin C. Kirkup, Walter Reed Army Institute of Research (United States)
David Craft, Walter Reed Army Institute of Research (United States)
Paige E. Waterman, Walter Reed Army Institute of Research (United States)
Emil P. Lesho, Walter Reed Army Institute of Research (United States)
Umaru Bangurae, Mercy Hospital Research Lab. (Sierra Leone)
Rashid Ansumana, Mercy Hospital Research Lab. (Sierra Leone)


Published in SPIE Proceedings Vol. 8371:
Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
Sárka O. Southern; B. V. K. Vijaya Kumar; Salil Prabhakar; Arend H. J. Kolk; Kevin N. Montgomery; Arun A. Ross; Carl W. Taylor, Editor(s)

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