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Proceedings Paper

Porosity at photo-induced fat cell lipolysis
Author(s): V. A. Doubrovsky; I. Yu. Yanina; V. V. Tuchin
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Paper Abstract

The "specific structures" on the fat cells' membranes in vitro as a result of photodynamic treatment was registered. These structures were identified as cytoplasm/oil microdrops flowed out through the pores in the membranes. The impact of Brilliant Green dissolved in water-ethanol solutions and irradiation by a LED lamp on the quantity and size of "specific structures" on the membranes was investigated. It was demonstrated that optical selective action on fat cells sensitized by Brilliant Green led to the growth of "specific structures" (pores) number during the time interval after light exposure. A high degree of correlation between the optical clearing of fat tissue and quantity of "specific structures" (pores) was found. This result proves our early prediction about mechanism of light-induced fat cells' lipolysis via increased cell membrane porosity.

Paper Details

Date Published: 8 May 2012
PDF: 9 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842748 (8 May 2012); doi: 10.1117/12.924117
Show Author Affiliations
V. A. Doubrovsky, Saratov State Medical Univ. (Russian Federation)
I. Yu. Yanina, Saratov State Medical Univ. (Russian Federation)
N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
V. V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics (Russian Federation)
Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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