Share Email Print
cover

Proceedings Paper

Reconstructing in-vivo reflectance spectrum of pigmented skin lesion by Monte Carlo simulation
Author(s): Shuang Wang; Qingli He; Jianhua Zhao; Harvey Lui; Haishan Zeng
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

In dermatology applications, diffuse reflectance spectroscopy has been extensively investigated as a promising tool for the noninvasive method to distinguish melanoma from benign pigmented skin lesion (nevus), which is concentrated with the skin chromophores like melanin and hemoglobin. We carried out a theoretical study to examine melanin distribution in human skin tissue and establish a practical optical model for further pigmented skin investigation. The theoretical simulation was using junctional nevus as an example. A multiple layer skin optical model was developed on established anatomy structures of skin, the published optical parameters of different skin layers, blood and melanin. Monte Carlo simulation was used to model the interaction between excitation light and skin tissue and rebuild the diffuse reflectance process from skin tissue. A testified methodology was adopted to determine melanin contents in human skin based on in vivo diffuse reflectance spectra. The rebuild diffuse reflectance spectra were investigated by adding melanin into different layers of the theoretical model. One of in vivo reflectance spectra from Junctional nevi and their surrounding normal skin was studied by compare the ratio between nevus and normal skin tissue in both the experimental and simulated diffuse reflectance spectra. The simulation result showed a good agreement with our clinical measurements, which indicated that our research method, including the spectral ratio method, skin optical model and modifying the melanin content in the model, could be applied in further theoretical simulation of pigmented skin lesions.

Paper Details

Date Published: 14 March 2012
PDF: 6 pages
Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290Y (14 March 2012); doi: 10.1117/12.923858
Show Author Affiliations
Shuang Wang, Northwest Univ. (China)
British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia and Vancouver Coastal Health Research Institute (Canada)
Qingli He, Northwest Univ. (China)
Jianhua Zhao, Northwest Univ. (China)
British Columbia Cancer Research Ctr. (Canada)
Harvey Lui, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia and Vancouver Coastal Health Research Institute (Canada)
Haishan Zeng, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia and Vancouver Coastal Health Research Institute (Canada)


Published in SPIE Proceedings Vol. 8329:
Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top