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Proceedings Paper

The development of skin immersion clearing method for increasing of laser exposure efficiency on subcutaneous objects
Author(s): Alexandra M. Kozina; Elina A. Genina; Georgy S. Terentyuk; Artem G. Terentyuk; Alexey N. Bashkatov; Valery V. Tuchin; Boris N. Khlebtsov
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Paper Abstract

In this paper we have studied effect of a hyperosmotic optical clearing agent (OCA), such as polyethylene glycol, on the fluorescence intensity from a target located in subcutaneous area in the model experiments. As a fluorescence agent the nanocomposite including gold nanorods with hematophorphyrin was used. The remitted fluorescent signal traveling to the tissue surface was monitored over time as the tissue was treated with the OCA. The detected fluorescent signal increased as the scattering in tissue samples was substantially reduced. The study has shown how OCA can be used to improve the detected signal at localization of subcutaneous target tissue at the photothermal or photodynamic therapy. Immersion clearing of skin can be also useful for improvement of laser exposure efficiency due to the increasing of light penetration depth.

Paper Details

Date Published: 8 May 2012
PDF: 9 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842726 (8 May 2012); doi: 10.1117/12.922725
Show Author Affiliations
Alexandra M. Kozina, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Elina A. Genina, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Georgy S. Terentyuk, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Artem G. Terentyuk, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Alexey N. Bashkatov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Univ. of Oulu (Finland)
Boris N. Khlebtsov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)


Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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