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Proceedings Paper

Studying circulating prostate cancer cells by in-vivo flow cytometer
Author(s): Jin Guo; Zhengqin Gu; Tong Chen; Cheng Wang; Xunbin Wei
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Paper Abstract

Prostate cancer is the most common malignancy in American men and the second leading cause of deaths from cancer, after lung cancer. The tumor usually grows slowly and remains confined to the gland for many years. As the cancer advances, however, it can metastasize throughout other areas of the body, such as the bones, lungs, and liver. Surgical resection, hormonal therapy, chemotherapy and radiation therapy are the foundation of current prostate cancer therapies. Treatments for prostate cause both short- and long-term side effects that may be difficult to accept. Molecular mechanisms of prostate cancer metastasis need to be understood better and new therapies must be developed to selectively target to unique characteristics of cancer cell growth and metastasis. We have developed the "in vivo microscopy" to study the mechanisms that govern prostate cancer cell spread through the microenvironment in vivo in real-time confocal near-infrared fluorescence imaging. A recently developed "in vivo flow cytometer" and optical imaging are used to assess prostate cancer cell spreading and the circulation kinetics of prostate cancer cells. We have measured the depletion kinetics of cancer cells with different metastatic potential. Interestingly, more invasive PC-3 prostate cancer cells are depleted faster from the circulation than LNCaP cells.

Paper Details

Date Published: 13 March 2012
PDF: 8 pages
Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290V (13 March 2012); doi: 10.1117/12.922040
Show Author Affiliations
Jin Guo, Fudan Univ. (China)
Zhengqin Gu, Xinhua Hospital, Shanghai Jiaotong Univ. (China)
Tong Chen, Huashen Hospital, Fudan Univ. (China)
Cheng Wang, Univ. of Shanghai for Science and Technology (China)
Xunbin Wei, Fudan Univ. (China)
Shanghai Jiaotong Univ. (China)

Published in SPIE Proceedings Vol. 8329:
Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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