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Proceedings Paper

Spectroscopic detection of chemotherapeutics and antioxidants
Author(s): Ines Latka; Roman Grüner; Christian Matthäus; Benjamin Dietzek; W. Werncke; Jürgen Lademann; Jürgen Popp
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Paper Abstract

The hand-foot-syndrome presents a severe dermal side-effect of chemotherapeutic cancer treatment. The cause of this side-effect is the elimination of systemically administered chemotherapeutics with the sweat. Transported to the skin surface, the drugs subsequently penetrate into the skin in the manner of topically applied substances. Upon accumulation of the chemotherapeutics in the skin the drugs destroy cells and tissue - in the same way as they are supposed to act in cancer cells. Aiming at the development of strategies to illuminate the molecular mechanism underlying the handfoot- syndrome (and, in a second step, strategies to prevent this severe side-effect), it might be important to evaluate the concentration and distribution of chemotherapeutics and antioxidants in the human skin. The latter can be estimated by the carotenoid concentration, as carotenoids serve as marker substances for the dermal antioxidative status.Following the objectives outlined above, this contribution presents a spectroscopic study aiming at the detection and quantification of carotenoids and selected chemotherapeutics in human skin. To this end, spontaneous Raman scattering and coherent anti-Stokes Raman scattering (CARS) microspectroscopy are combined with two-photon excited fluorescence. While the latter technique is Please verify that (1) all pages are present, (2) all figures are correct, (3) all fonts and special characters are correct, and (4) all text and figures fit within the red margin lines shown on this review document. Complete formatting information is available at Return to your MySPIE To Do List at and approve or disapprove this submission. Your manuscript will not be published without this approval.restricted to the detection of fluorescent chemotherapeutics, e.g., doxorubicin, the vibrational spectroscopic techniques can - in principle - be applied to any type of analyte molecules. Furthermore, we will present the monitoring of doxorubicin uptake during experiments.

Paper Details

Date Published: 8 May 2012
PDF: 14 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84272O (8 May 2012); doi: 10.1117/12.921768
Show Author Affiliations
Ines Latka, Institut für Photonische Technologien e.V. (Germany)
Roman Grüner, Institut für Photonische Technologien e.V. (Germany)
Christian Matthäus, Institut für Photonische Technologien e.V. (Germany)
Benjamin Dietzek, Institut für Photonische Technologien e.V. (Germany)
Friedrich-Schiller-Univ. Jena (Germany)
W. Werncke, Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (Germany)
Jürgen Lademann, Charité Universitätsmedizin Berlin (Germany)
Jürgen Popp, Institut für Photonische Technologien e.V. (Germany)
Friedrich-Schiller-Univ. Jena (Germany)

Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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