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Proceedings Paper

Longitudinal evaluation of patients with oral potentially malignant disorders using optical imaging and spectroscopy
Author(s): Richard A. Schwarz; Mark C. Pierce; Sharon Mondrik; Wen Gao; Mary K. Quinn; Vijayashree Bhattar; Michelle D. Williams; Nadarajah Vigneswaran; Ann M. Gillenwater; Rebecca Richards-Kortum
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Paper Abstract

Dysplastic and cancerous alterations in oral tissue can be detected noninvasively in vivo using optical techniques including autofluorescence imaging, high-resolution imaging, and spectroscopy. Interim results are presented from a longitudinal study in which optical imaging and spectroscopy were used to evaluate the progression of lesions over time in patients at high risk for development of oral cancer. Over 100 patients with oral potentially malignant disorders have been enrolled in the study to date. Areas of concern in the oral cavity are measured using widefield autofluorescence imaging and depth-sensitive optical spectroscopy during successive clinical visits. Autofluorescence intensity patterns and autofluorescence spectra are tracked over time and correlated with clinical observations. Patients whose lesions progress and who undergo surgery are also measured in the operating room immediately prior to surgery using autofluorescence imaging and spectroscopy, with the addition of intraoperative high-resolution imaging to characterize nuclear size, nuclear crowding, and tissue architecture at selected sites. Optical measurements are compared to histopathology results from biopsies and surgical specimens collected from the measured sites. Autofluorescence imaging and spectroscopy measurements are continued during post-surgery followup visits. We examined correlations between clinical impression and optical classification over time with an average followup period of 4 months. The data collected to date suggest that multimodal optical techniques may aid in noninvasive monitoring of the progression of oral premalignant lesions, biopsy site selection, and accurate delineation of lesion extent during surgery.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82071J (9 February 2012); doi: 10.1117/12.921162
Show Author Affiliations
Richard A. Schwarz, Rice Univ. (United States)
Mark C. Pierce, Rutgers Univ. (United States)
Sharon Mondrik, Rice Univ. (United States)
Wen Gao, Rice Univ. (United States)
Mary K. Quinn, Rice Univ. (United States)
Vijayashree Bhattar, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Michelle D. Williams, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Nadarajah Vigneswaran, The Univ. of Texas Dental Branch at Houston (United States)
Ann M. Gillenwater, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rebecca Richards-Kortum, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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