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Proceedings Paper

Molecular targeting in childhood malignancies using nanoparticles
Author(s): Noriko Satake; Gustavo Barisone; Elva Diaz; Nitin Nitin; Jan Nolta; Kit Lam
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Paper Abstract

The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.

Paper Details

Date Published: 7 May 2012
PDF: 6 pages
Proc. SPIE 8373, Micro- and Nanotechnology Sensors, Systems, and Applications IV, 83730N (7 May 2012); doi: 10.1117/12.920917
Show Author Affiliations
Noriko Satake, Univ. of California, Davis (United States)
Gustavo Barisone, Univ. of California, Davis (United States)
Elva Diaz, Univ. of California, Davis (United States)
Nitin Nitin, Univ. of California, Davis (United States)
Jan Nolta, Univ. of California, Davis (United States)
Kit Lam, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 8373:
Micro- and Nanotechnology Sensors, Systems, and Applications IV
Thomas George; M. Saif Islam; Achyut Dutta, Editor(s)

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