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Proceedings Paper

Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography
Author(s): Hrebesh M. Subhash; Anh Nguyen-Huynh; Ruikang K. Wang; Steven L. Jacques; Alfred L. Nuttall
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Paper Abstract

We describe a novel method for the detection of the tiny motions of the middle ear (ME) ossicles and their morphological features with a spectral-domain phase sensitive optical coherence tomography (PS-OCT). Laser Doppler Vibrometry (LDV) and its variations are the most extensively used methods for studding the vibrational modes of the ME. However, most techniques are limited to single point analysis methods, and do not have the ability to provide depth resolved simultaneous imaging of multiple points on the ossicles especially with the intact eardrum. Consequently, the methods have the limited ability to provide relative vibration information at these points. In this study, we demonstrated the feasibility of using PS-OCT for simultaneous depth resolved imaging of both vibration information and morphological features in a cadaver human middle ear with high sensitivity and resolution. This technique has the potential to provide meaningful vibration of ossicles with a vibration sensitivity of ~0.5nm at 1kHz acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at sub-nanometer scale.

Paper Details

Date Published: 17 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82072C (17 February 2012); doi: 10.1117/12.920839
Show Author Affiliations
Hrebesh M. Subhash, Oregon Health & Science Univ. (United States)
Anh Nguyen-Huynh, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Univ. of Washington (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory M.D.; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg M.D.; Melissa J. Suter; Brian Jet-Fei Wong M.D.; Justus F. Ilgner M.D.; Stephen Lam; Bodo E. Knudsen M.D.; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney M.D.; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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