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Proceedings Paper

Methodology for assessment of structural vibrations by spectral domain optical coherence tomography
Author(s): Simon S. Gao; Patrick Raphael; Anping Xia; Jesung Park; Esteban Carbajal; Brian E. Applegate; John S. Oghalai
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Paper Abstract

Clinical diagnosis of cochlear dysfunction typically remains incomplete due to a lack of proper diagnostic methods. Medical imaging modalities can only detect gross changes in the cochlea, and non-invasive in vivo cochlear measurements are scarce. As a result, extensive efforts have been made to adapt optical coherence tomography (OCT) techniques to analyze and study the cochlea. Herein, we detail the methods for measuring vibration using OCT. We used spectral domain OCT with ~950 nm as the center wavelength and a bandwidth of ~80 nm. The custom spectrometer used was based on a high speed line scan camera which is capable of line rates up to 28 kHz. The signal-to- noise ratio of the system was ~90 dB. The data collection and processing software was written in LabVIEW and MATLAB. We tested whether streaming directly from the camera, writing the data to multiple hard drives in the RAID- 0 configuration, and processing using the GPU shortened experiment times. We then analyzed the A-line phase noise over several hundred milliseconds and growth curves from a piezoelectric element. We believe this is the first step towards a diagnostic device which generates vibration information of cochlear structures.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82072B (9 February 2012); doi: 10.1117/12.920798
Show Author Affiliations
Simon S. Gao, Rice Univ (United States)
Patrick Raphael, Stanford Univ. (United States)
Anping Xia, Stanford Univ. (United States)
Jesung Park, Texas A&M Univ. (United States)
Esteban Carbajal, Texas A&M Univ. (United States)
Brian E. Applegate, Texas A&M Univ. (United States)
John S. Oghalai, Stanford Univ. (United States)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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