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Proceedings Paper

Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies
Author(s): L. M. Almond; J. Hutchings; G. R. Lloyd; J. Francis-Jones; N. Stone; H. Barr; C. Kendall
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Paper Abstract

Raman spectroscopy is an inelastic scattering technique capable of probing the biochemical changes associated with neoplastic progression in oesophageal tissue. Custom-built fibre-optic Raman probes could potentially provide opportunities for in vivo endoscopic diagnosis of pre-cancerous oesophageal lesions and targeted early therapy. However, prior to commencing a clinical trial convincing ex vivo work must demonstrate multi-operator, multi-centre and multi-system reliability. We report spectral consistency between two operators who independently evaluated two optically identical probes ex vivo. In addition, we demonstrate compatibility with high-definition white light endoscopes and narrow band imaging systems highlighting the potential for future endoscopic multi-modality imaging in the oesophagus.

Paper Details

Date Published: 31 January 2012
PDF: 7 pages
Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190L (31 January 2012); doi: 10.1117/12.919876
Show Author Affiliations
L. M. Almond, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
J. Hutchings, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
G. R. Lloyd, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
J. Francis-Jones, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
N. Stone, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
H. Barr, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
C. Kendall, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)


Published in SPIE Proceedings Vol. 8219:
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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