Share Email Print
cover

Proceedings Paper

Assessing the performance of spectroscopic models for cancer diagnostics using cross-validation and permutation testing
Author(s): G. R. Lloyd; J. Hutchings; L. M. Almond; H. Barr; C. Kendall; N. Stone
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Multivariate classifiers (such as Linear Discriminant Analysis, Support Vector Machines etc) are known to be useful tools for making diagnostic decisions based on spectroscopic data. However, robust techniques for assessing their performance (e.g. by sensitivity and specificity) are vital if the application of these methods is to be successful in the clinic. In this work the application of repeated cross-validation for estimating confidence intervals for sensitivity and specificity of multivariate classifiers is presented. Furthermore, permutation testing is presented as a suitable technique for estimating the probability of obtaining the observed sensitivity and specificity by chance. Both approaches are demonstrated through their application to a Raman spectroscopic model of gastrointestinal cancer.

Paper Details

Date Published: 1 February 2012
PDF: 6 pages
Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190C (1 February 2012); doi: 10.1117/12.919864
Show Author Affiliations
G. R. Lloyd, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
J. Hutchings, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
L. M. Almond, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
H. Barr, Cranfield Health (United Kingdom)
Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
C. Kendall, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)
N. Stone, Gloucestershire Hospitals NHS Foundation Trust (United Kingdom)
Cranfield Health (United Kingdom)


Published in SPIE Proceedings Vol. 8219:
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

© SPIE. Terms of Use
Back to Top