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Proceedings Paper

Accurate determination of the complex refractive index of solid tissue-equivalent phantom
Author(s): Jin Wang; Qing Ye; Zhichao Deng; Wenyuan Zhou; Chunping Zhang; Jianguo Tian
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Paper Abstract

Tissue-equivalent phantom is becoming widespread as a substitute in the biological field to verify optical theories, test measuring systems and study the tissue performances for varying boundary conditions, sample size and shape at a quantitative level. Compared with phantoms made with Intralipid solution, ink and other liquid substances, phantom in solid state is stable over time, reproducible, easy to handle and has been testified to be a suitable optical simulator in the visible and near-infrared region. We present accurate determination of the complex refractive index (RI) of a solid tissueequivalent phantom using extended derivative total reflection method (EDTRM). Scattering phantoms in solid state were measured for p-polarized and s-polarized incident light respectively. The reflectance curves of the sample as a function of incident angle were recorded. The real part of RI is directly determined by derivative of the reflectance curve, and the imaginary part is obtained from nonlinear fitting based on the Fresnel equation and Nelder-Mead simplex method. The EDTRM method is applicable for RI measurement of high scattering media such as biotissue, solid tissue-equivalent phantom and bulk material. The obtained RI information can be used in the study of tissue optics and biomedical field.

Paper Details

Date Published: 8 May 2012
PDF: 6 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842729 (8 May 2012); doi: 10.1117/12.919832
Show Author Affiliations
Jin Wang, Nankai Univ. (China)
Qing Ye, Nankai Univ. (China)
Zhichao Deng, Nankai Univ. (China)
Wenyuan Zhou, Nankai Univ. (China)
Chunping Zhang, Nankai Univ. (China)
Jianguo Tian, Nankai Univ. (China)

Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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