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Proceedings Paper

Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals
Author(s): Hongyang Lu; Peng Miao; Qi Liu; Yao Li; Shanbao Tong
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Paper Abstract

Optical intrinsic signals (OIS) and laser speckle contrast imaging (LSCI) have been used for years in the study of the cerebral blood flow (CBF) and hemodynamic responses to the neural activity under functional stimulation. So far, most in vivo rodent experiments are based on the anesthesia model when the animals are in unconscious and restrained conditions. The influences of anesthesia on the neural activity have been documented in literature. In this study, we designed a miniature head-mounted dual-modal imager in freely moving animals that could monitor in real time the coupling of local oxygen consumption and blood perfusion of CBF by integrating different imaging modalities of OIS and LSCI. The system facilitates the study the cortical hemodynamics and neural-hemodynamic coupling in real time in freely moving animals.

Paper Details

Date Published: 13 March 2012
PDF: 6 pages
Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290P (13 March 2012); doi: 10.1117/12.919133
Show Author Affiliations
Hongyang Lu, Shanghai Jiaotong Univ. (China)
Peng Miao, Shanghai Jiaotong Univ. (China)
Qi Liu, Shanghai Jiaotong Univ. (China)
Yao Li, Shanghai Jiaotong Univ. (China)
Shanbao Tong, Shanghai Jiaotong Univ. (China)


Published in SPIE Proceedings Vol. 8329:
Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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