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Proceedings Paper

Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy
Author(s): Yong Du; Rongjiao Zhao; Guohui Hao; Changsheng Guo; Zhi Hong
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Paper Abstract

Absorption spectra in the terahertz region between 6 and 66 cm-1 (0.2 ~ 2.0 THz) were measured for S-(+)-, R-(-) and RS-naproxen pharmaceutical molecules in crystalline form using time-domain terahertz spectroscopic (THz-TDS) technique at room temperature. Different absorption features were observed for the racemic RS-naproxen and its corresponding enantiomers (S-(+)- and R-(-)-naproxen). The observed THz absorption bands are strikingly sensitive to the change of subtle conformational structures despite that the isostructurality exists within such crystal molecules. The results show that the THz-TDS technique can be definitely used for distinguishing between chiral and racemic compounds in pharmaceutical and biological fields.

Paper Details

Date Published: 14 March 2012
PDF: 7 pages
Proc. SPIE 8330, Photonics and Optoelectronics Meetings (POEM) 2011: Laser and Terahertz Science and Technology, 83300X (14 March 2012); doi: 10.1117/12.918840
Show Author Affiliations
Yong Du, China Jiliang Univ. (China)
Rongjiao Zhao, China Jiliang Univ. (China)
Guohui Hao, China Jiliang Univ. (China)
Changsheng Guo, China Jiliang Univ. (China)
Zhi Hong, China Jiliang Univ. (China)


Published in SPIE Proceedings Vol. 8330:
Photonics and Optoelectronics Meetings (POEM) 2011: Laser and Terahertz Science and Technology
Jianquan Yao; X. C. Zhang; Dapeng Yan; Jinsong Liu, Editor(s)

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