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Proceedings Paper

In vivo imaging and quantification of iron oxide nanoparticle uptake and biodistribution
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Paper Abstract

Recent advances in nanotechnology have allowed for the effective use of iron oxide nanoparticles (IONPs) for cancer imaging and therapy. When activated by an alternating magnetic field (AMF), intra-tumoral IONPs have been effective at controlling tumor growth in rodent models. To accurately plan and assess IONP-based therapies in clinical patients, noninvasive and quantitative imaging technique for the assessment of IONP uptake and biodistribution will be necessary. Proven techniques such as confocal, light and electron microscopy, histochemical iron staining, ICP-MS, fluorescent labeled mNPs and magnetic spectroscopy of Brownian motion (MSB), are being used to assess and quantify IONPs in vitro and in ex vivo tissues. However, a proven noninvasive in vivo IONP imaging technique has not yet been developed. In this study we have demonstrated the shortcomings of computed tomography (CT) and magnetic resonance imaging (MRI) for effectively observing and quantifying iron /IONP concentrations in the clinical setting. Despite the poor outcomes of CT and standard MR sequences in the therapeutic concentration range, ultra-short T2 MRI methods such as, Sweep Imaging With Fourier Transformation (SWIFT), provide a positive iron contrast enhancement and a reduced signal to noise ratio. Ongoing software development and phantom and in vivo studies, will further optimize this technique, providing accurate, clinically-relevant IONP biodistribution information.

Paper Details

Date Published: 14 April 2012
PDF: 9 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83170R (14 April 2012); doi: 10.1117/12.916097
Show Author Affiliations
P. Jacks Hoopes, Thayer School of Engineering at Dartmouth (United States)
Dartmouth Medical School (United States)
Alicia A. Petryk, Thayer School of Engineering at Dartmouth (United States)
Barjor Gimi, Dartmouth Medical School (United States)
Andrew J. Giustini, Thayer School of Engineering at Dartmouth (United States)
Dartmouth Medical School (United States)
John B. Weaver, Thayer School of Engineering at Dartmouth (United States)
Dartmouth Medical School (United States)
John Bischof, Univ. of Minnesota, Twin Cities (United States)
Ryan Chamberlain, Univ. of Minnesota, Twin Cities (United States)
Michael Garwood, Ctr. for Magnetic Resonance Research, Univ. of Minnesota, Twin Cities (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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