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Proceedings Paper

Micro- and nanostructured polymer substrates for biomedical applications
Author(s): Jasmin Althaus; Prabitha Urwyler; Celestino Padeste; Roman Heuberger; Hans Deyhle; Helmut Schift; Jens Gobrecht; Uwe Pieles; Dieter Scharnweber; Kirsten Peters; Bert Müller
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Paper Abstract

Polymer implants are interesting alternatives to the contemporary load-bearing implants made from metals. Polyetheretherketone (PEEK), a well-established biomaterial for example, is not only iso-elastic to bone but also permits investigating the surrounding soft tissues using magnetic resonance imaging or computed tomography, which is particularly important for cancer patients. The commercially available PEEK bone implants, however, require costly coatings, which restricts their usage. As an alternative to coatings, plasma activation can be applied. The present paper shows the plasma-induced preparation of nanostructures on polymer films and on injection-molded micro-cantilever arrays and the associated chemical modifications of the surface. In vitro cell experiments indicate the suitability of the activation process. In addition, we show that microstructures such as micro-grooves 1 μm deep and 20 μm wide cause cell alignment. The combination of micro-injection molding, simultaneous microstructuring using inserts/bioreplica and plasma treatments permits the preparation of polymer implants with nature-analogue, anisotropic micro- and nanostructures.

Paper Details

Date Published: 4 April 2012
PDF: 16 pages
Proc. SPIE 8339, Bioinspiration, Biomimetics, and Bioreplication 2012, 83390Q (4 April 2012); doi: 10.1117/12.915235
Show Author Affiliations
Jasmin Althaus, Univ. of Basel (Switzerland)
Paul Scherrer Institut (Switzerland)
Univ. of Applied Sciences and Arts Northwestern Switzerland (Switzerland)
Prabitha Urwyler, Univ. of Basel (Switzerland)
Paul Scherrer Institut (Switzerland)
Celestino Padeste, Paul Scherrer Institut (Switzerland)
Roman Heuberger, RMS Foundation (Switzerland)
Hans Deyhle, Univ. of Basel (Switzerland)
Helmut Schift, Paul Scherrer Institut (Switzerland)
Jens Gobrecht, Paul Scherrer Institut (Switzerland)
Univ. of Applied Sciences and Arts Northwestern Switzerland (Switzerland)
Uwe Pieles, Univ. of Applied Sciences and Arts Northwestern Switzerland (Switzerland)
Dieter Scharnweber, Technical Univ. Dresden (Germany)
Kirsten Peters, Univ. of Rostock (Germany)
Bert Müller, Univ. of Basel (Switzerland)

Published in SPIE Proceedings Vol. 8339:
Bioinspiration, Biomimetics, and Bioreplication 2012
Akhlesh Lakhtakia, Editor(s)

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