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Proceedings Paper

Toward bioinspired parylene-C coatings of implant surfaces
Author(s): Lai Wei; Akhlesh Lakhtakia
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Paper Abstract

The external surfaces of an implanted prosthesis must be biocompatible. As the properties of a biological surface vary, often gradually but also abruptly, the implant surface should be endowed with a gradient of surface roughness and wettability for good integration with proteins and cells. We have made free-standing, flexible, fibrous, nano/micro-textured thin films of parylene-C with thickness-controlled surface morphology and hydrophobicity; furthermore, varying degrees of hydrophilicity are displayed after oxygen-plasma treatment. The bioinspired thin films are mechanically robust and have been shown to support both protein binding and cellular attachment as well as growth. By conformally covering an implant surface with patches of these thin films of varying thickness and oxygen-plasma-treatment duration, gradients of protein/cell attachment can be tailored and thus tissue integration can be managed on different parts of the implant surface.

Paper Details

Date Published: 4 April 2012
PDF: 10 pages
Proc. SPIE 8339, Bioinspiration, Biomimetics, and Bioreplication 2012, 83390R (4 April 2012); doi: 10.1117/12.914939
Show Author Affiliations
Lai Wei, The Pennsylvania State Univ. (United States)
Akhlesh Lakhtakia, The Pennsylvania State Univ. (United States)

Published in SPIE Proceedings Vol. 8339:
Bioinspiration, Biomimetics, and Bioreplication 2012
Akhlesh Lakhtakia, Editor(s)

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