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Proceedings Paper

Noninvasive optoacoustic system for rapid diagnostics and management of circulatory shock
Author(s): Rinat O. Esenaliev; Irene Y. Petrov; Yuriy Petrov; Michael Kinsky; Donald S. Prough
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Paper Abstract

Circulatory shock is lethal, if not promptly diagnosed and effectively treated. Typically, circulatory shock resuscitation is guided by blood pressure, heart rate, and mental status, which have poor predictive value. In patients, in whom early goaldirected therapy was applied using central venous oxygenation measurement, a substantial reduction of mortality was reported (from 46.5% to 30%). However, central venous catheterization is invasive, time-consuming and often results in complications. We proposed to use the optoacoustic technique for noninvasive, rapid assessment of central venous oxygenation. In our previous works we demonstrated that the optoacoustic technique can provide measurement of blood oxygenation in veins and arteries due to high contrast and high resolution. In this work we developed a novel optoacoustic system for noninvasive, automatic, real-time, and continuous measurement of central venous oxygenation. We performed pilot clinical tests of the system in human subjects with different oxygenation in the internal jugular vein and subclavian vein. A novel optoacoustic interface incorporating highly-sensitive optoacoustic probes and standard ultrasound imaging probes were developed and built for the study. Ultrasound imaging systems Vivid i and hand-held Vscan (GE Healthcare) as well as Site-Rite 5 (C.R. Bard) were used in the study. We developed a special algorithm for oxygenation monitoring with minimal influence of overlying tissue. The data demonstrate that the system provides precise measurement of venous oxygenation continuously and in real time. Both current value of the venous oxygenation and trend (in absolute values and for specified time intervals) are displayed in the system. The data indicate that: 1) the optoacoustic system developed by our group is capable of noninvasive measurement of blood oxygenation in specific veins; 2) clinical ultrasound imaging systems can facilitate optoacoustic probing of specific blood vessels; 3) the optoacoustic system provides noninvasive monitoring during rapid changes in blood oxygenation.

Paper Details

Date Published: 28 February 2012
PDF: 5 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230F (28 February 2012); doi: 10.1117/12.914653
Show Author Affiliations
Rinat O. Esenaliev, The Univ. of Texas Medical Branch (United States)
Irene Y. Petrov, The Univ. of Texas Medical Branch (United States)
Yuriy Petrov, The Univ. of Texas Medical Branch (United States)
Michael Kinsky, The Univ. of Texas Medical Branch (United States)
Donald S. Prough, The Univ. of Texas Medical Branch (United States)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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