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Proceedings Paper

Brain tumor modeling: glioma growth and interaction with chemotherapy
Author(s): Hossein Yousefi Banaem; Alireza Ahmadian; Hooshangh Saberi; Alireza Daneshmehr; Davood Khodadad
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Paper Abstract

In last decade increasingly mathematical models of tumor growths have been studied, particularly on solid tumors which growth mainly caused by cellular proliferation. In this paper we propose a modified model to simulate the growth of gliomas in different stages. Glioma growth is modeled by a reaction-advection-diffusion. We begin with a model of untreated gliomas and continue with models of polyclonal glioma following chemotherapy. From relatively simple assumptions involving homogeneous brain tissue bounded by a few gross anatomical landmarks (ventricles and skull) the models have been expanded to include heterogeneous brain tissue with different motilities of glioma cells in grey and white matter. Tumor growth is characterized by a dangerous change in the control mechanisms, which normally maintain a balance between the rate of proliferation and the rate of apoptosis (controlled cell death). Result shows that this model closes to clinical finding and can simulate brain tumor behavior properly.

Paper Details

Date Published: 1 October 2011
PDF: 6 pages
Proc. SPIE 8285, International Conference on Graphic and Image Processing (ICGIP 2011), 82851M (1 October 2011); doi: 10.1117/12.913432
Show Author Affiliations
Hossein Yousefi Banaem, Tehran Univ. of Medical Science (Iran, Islamic Republic of)
Alireza Ahmadian, Tehran Univ. of Medical Science (Iran, Islamic Republic of)
Hooshangh Saberi, Tehran Univ. of Medical Science (Iran, Islamic Republic of)
Alireza Daneshmehr, Univ. of Tehran (Iran, Islamic Republic of)
Davood Khodadad, Tehran Univ. of Medical Science (Iran, Islamic Republic of)


Published in SPIE Proceedings Vol. 8285:
International Conference on Graphic and Image Processing (ICGIP 2011)

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