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Proceedings Paper

Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR
Author(s): Kai Ding; Kunlin Cao; Wilson Miller; Gary Christensen; Joseph Reinhardt; Stanley Benedict; Bruce Libby; Ke Sheng
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Paper Abstract

Radiation induced pulmonary diseases can change the tissue material properties of lung parenchyma and the mechanics of the respiratory system. Recent advances in multi-detector-row CT (MDCT), 4DCT respiratory gating methods, and image processing techniques enable us to follow and measure those changes noninvasively during radiation therapy at a regional level. This study compares the 4DCT based ventilation measurement with the results from hyperpolarized helium-3 MR using the cumulative distribution function maps and the relative overlap (RO) statistic. We show that the similarity between the two measurements increases as the increase of the B-Spline grid spacing and Laplacian weighting which result a smoother ventilation map. The best similarity is found with weighting of 0.5 for linear elasticity and B-Spline grid spacing of 32 mm. Future work is to improve the lung image registration algorithm by incorporating hyperpolarized helium-3 MR information so as to improve its physiological modeling of the lung tissue deformation.

Paper Details

Date Published: 5 April 2012
PDF: 7 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83171E (5 April 2012); doi: 10.1117/12.912793
Show Author Affiliations
Kai Ding, Univ. of Virginia (United States)
Univ. of Iowa (United States)
Kunlin Cao, The Univ. of Iowa (United States)
Wilson Miller, Univ. of Virginia (United States)
Gary Christensen, The Univ. of Iowa (United States)
Joseph Reinhardt, The Univ. of Iowa (United States)
Stanley Benedict, Univ. of Virginia (United States)
Bruce Libby, Univ. of Virginia (United States)
Ke Sheng, Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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