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Proceedings Paper

Breast tissue composition and breast density measurements from ultrasound tomography
Author(s): Mark Sak; Neb Duric; Norman Boyd; Peter Littrup; Erik West; Cuiping Li
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Paper Abstract

It is known that breast cancer risk is greater in women with higher breast densities. Currently, breast density is measured using mammographic percent density, defined as the ratio of fibroglandular to total breast area on a two dimensional mammogram. Alternatively, systems that use ultrasound tomography (UST) create tomographic sound speed images of the patient's breast. These volumetric images can be useful as a diagnostic aid because it is also known that sound speed of tissue is proportional to the density of the tissue. The purpose of this work is to expand on the comparisons of the two imaging modalities by introducing new ultrasound tomography measurements that separate and quantify the fatty and dense tissue distributions within the breast. A total of 249 patients were imaged using both imaging modalities. By using k-means clustering, correlations beyond the volume averaged sound speed of the ultrasound images and the mammographic percent density were investigated. Both the ultrasound and mammographic images were separated into dense and fatty regions. Various associations between the global breast properties as well as separate tissue components were found.

Paper Details

Date Published: 25 February 2012
PDF: 7 pages
Proc. SPIE 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy, 83200Q (25 February 2012); doi: 10.1117/12.912407
Show Author Affiliations
Mark Sak, Karmanos Cancer Institute, Wayne State Univ. (United States)
Neb Duric, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Norman Boyd, Princess Margaret Hospital (Canada)
Peter Littrup, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Erik West, Delphinus Medical Technologies (United States)
Cuiping Li, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)


Published in SPIE Proceedings Vol. 8320:
Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy
Johan G. Bosch; Marvin M. Doyley, Editor(s)

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