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Proceedings Paper

Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation
Author(s): M. R. Nasiri-Avanaki; Ahmed Aber; S. A. Hojjatoleslami; Mano Sira; John B. Schofield; Carole Jones; A. Gh. Podoleanu
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Paper Abstract

Basal cell carcinoma (BCC) is the most common form of skin cancer. To improve the diagnostic accuracy, additional non-invasive methods of making a preliminary diagnosis have been sought. We have implemented an En-Face optical coherence tomography (OCT) for this study in which the dynamic focus was integrated into it. With the dynamic focus scheme, the coherence gate moves synchronously with the peak of confocal gate determined by the confocal interface optics. The transversal resolution is then conserved throughout the depth range and an enhanced signal is returned from all depths. The Basal Cell Carcinoma specimens were obtained from the eyelid a patient. The specimens under went analysis by DF-OCT imaging. We searched for remarkable features that were visualized by OCT and compared these findings with features presented in the histology slices.

Paper Details

Date Published: 9 February 2012
PDF: 7 pages
Proc. SPIE 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X, 82252J (9 February 2012); doi: 10.1117/12.912081
Show Author Affiliations
M. R. Nasiri-Avanaki, Univ. of Kent (United Kingdom)
St Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
Ahmed Aber, St Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
S. A. Hojjatoleslami, Univ. of Kent (United Kingdom)
Mano Sira, Hermitage Lane Maidstone Hospital (United Kingdom)
John B. Schofield, Preston Hall Hospital (United Kingdom)
Carole Jones, St Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
A. Gh. Podoleanu, Univ. of Kent (United Kingdom)


Published in SPIE Proceedings Vol. 8225:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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