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Proceedings Paper

Optimizing the delivery of deep brain stimulation using electrophysiological atlases and an inverse modeling approach
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Paper Abstract

The use of deep brain stimulation (DBS) for the treatment of neurological movement degenerative disorders requires the precise placement of the stimulating electrode and the determination of optimal stimulation parameters that maximize symptom relief (e.g. tremor, rigidity, movement difficulties, etc.) while minimizing undesired physiological side-effects. This study demonstrates the feasibility of determining the ideal electrode placement and stimulation current amplitude by performing a patient-specific multivariate optimization using electrophysiological atlases and a bioelectric finite element model of the brain. Using one clinical case as a preliminary test, the optimization routine is able to find the most efficacious electrode location while avoiding the high side-effect regions. Future work involves optimization validation clinically and improvement to the accuracy of the model.

Paper Details

Date Published: 17 February 2012
PDF: 8 pages
Proc. SPIE 8316, Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling, 83162Z (17 February 2012); doi: 10.1117/12.912024
Show Author Affiliations
Kay Sun, Vanderbilt Univ. (United States)
Srivatsan Pallavaram, Vanderbilt Univ. (United States)
William Rodriguez, Vanderbilt Univ. (United States)
Pierre-Francois D'Haese, Vanderbilt Univ. (United States)
Benoit M. Dawant, Vanderbilt Univ. (United States)
Michael I. Miga, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 8316:
Medical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling
David R. Holmes III; Kenneth H. Wong, Editor(s)

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