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Proceedings Paper

Exploration of microstructural abnormalities in borderline personality disorder
Author(s): Klaus H. Fritzsche; Romuald Brunner; Romy Henze; Hans-Peter Meinzer; Bram Stieltjes
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Paper Abstract

As with other mental disorders, the causes of borderline personality disorder (BPD) are complex and not fully understood. In this study we aimed to determine whether adults with BPD exhibit microstructural abnormalities using diffusion tensor imaging (DTI). 56 female right-handed individuals (age range, 14-18 years), 19 with a DSM-IV diagnosis of BPD, 18 patients with a DSM-IV defined current psychiatric disorder and 19 healthy control subjects were included. Groups were matched for age and IQ. DTI Images were analyzed using Tract-Based Spatial Statistics (TBSS). The analysis revealed significanty reduced fractional anisotropy (FA) values in the group of BPD patients compared to the normal controls. Similar FA reductions could not be found comparing BPD patients to clinical controls. Several clusters of increased radial (DR), axial (DA), and mean (MD) diffusivity were consistently identified when comparing the BPD patients to clinical as well as to healthy controls. None of the measures showed significant differences between the clinical and healthy controls. Diverse possible factors have been suggested to play a role in the disease, including environmental factors, neurobiological factors, or brain abnormalities. The presented results may play an important role in this ongoing debate.

Paper Details

Date Published: 14 April 2012
PDF: 9 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 831709 (14 April 2012); doi: 10.1117/12.911929
Show Author Affiliations
Klaus H. Fritzsche, German Cancer Research Ctr. (Germany)
Romuald Brunner, Ctr. for Psychosocial Medicine, Univ. of Heidelberg (Germany)
Romy Henze, Ctr. for Psychosocial Medicine, Univ. of Heidelberg (Germany)
Hans-Peter Meinzer, German Cancer Research Ctr. (Germany)
Bram Stieltjes, German Cancer Research Ctr. (Germany)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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