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Proceedings Paper

Advances in a fully integrated intravascular OCT-ultrasound system for cardiovascular imaging
Author(s): Joe Jing; Jiawen Li; Xiang Li; Jiechen Yin; Jun Zhang; Khiet Hoang; Pranav Patel; Qifa Zhou; Zhongping Chen
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Paper Abstract

Intracoronary optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are two popular techniques for the detection and determination of atherosclerosis. IVUS allows visualization of plaques while also providing a large penetration depth to determine plaque volume. Intracoronary OCT provides the ability to capture microscopic features associated with high risk plaque. Traditionally to utilize the benefits of both modalities, separate probes and systems had to be used one at a time to image a vessel. We present work required to create a combined OCT IVUS system capable of simultaneous imaging to detect atherosclerotic plaques. A novel integrated probe of size 0.69 mm OD featuring sequential placement of components was created to acquire co-registered images within small coronary vessels. By utilizing commercial graphics processing units (GPUs) real time visualization of acquired data is possible up to a maximum 48 frames per second per channel. In vitro studies on human coronary artery samples as well as in vivo studies in rabbits and pigs show various plaque buildups in both OCT and IVUS images which match histology results, demonstrating the capabilities of the system.

Paper Details

Date Published: 17 February 2012
PDF: 6 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82130Y (17 February 2012); doi: 10.1117/12.911635
Show Author Affiliations
Joe Jing, Univ. of California, Irvine (United States)
Jiawen Li, Univ. of California, Irvine (United States)
Xiang Li, The Univ. of Southern California (United States)
Jiechen Yin, Univ. of California, Irvine (United States)
Jun Zhang, Univ. of California, Irvine (United States)
Khiet Hoang, Beckman Laser Institute and Medical Clinic (United States)
Pranav Patel, Univ. of California, Irvine (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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