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Proceedings Paper

In vitro cell system for studying molecular mechanisms of action associated with low intensity focused ultrasound
Author(s): Meghedi Babakhanian; Richard E. Fan; Amit P. Mulgaonkar; Rahul Singh; Martin O. Culjat; Shahab M. Danesh; Ligia Toro; Warren Grundfest; William P. Melega
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Paper Abstract

Low intensity focused ultrasound (LIFU) is now being considered as a noninvasive brain therapy for clinical applications. We maintain that LIFU can efficiently deliver energy from outside the skull to target specific brain regions, effecting localized neuromodulation. However, the underlying molecular mechanisms that drive this LIFU-induced neuromodulation are not well-defined due, in part, to our lack of understanding of how particular sets of LIFU delivery parameters affect the outcome. To efficiently conduct multiple sweeps of different parameters and determine their effects, we have developed an in-vitro system to study the effects of LIFU on different types of cells grown in culture. Presently, we are evaluating how LIFU affects the ionic flux that may underlie neuronal excitation and inhibition observed in-vivo. The results of our in-vitro studies will provide a rationale for selection of optimal LIFU parameter to be used in subsequent in-vivo applications. Thus, a prototype ultrasound cell assay system has been developed to conduct these studies, and is described in this work.

Paper Details

Date Published: 28 February 2012
PDF: 6 pages
Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82140S (28 February 2012); doi: 10.1117/12.911602
Show Author Affiliations
Meghedi Babakhanian, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
Richard E. Fan, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
Amit P. Mulgaonkar, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
Rahul Singh, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
Martin O. Culjat, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
Shahab M. Danesh, Univ. of California, Los Angeles (United States)
Ligia Toro, Univ. of California, Los Angeles (United States)
Warren Grundfest, Ctr. for Advanced Surgical and Interventional Technology (United States)
Univ. of California, Los Angeles (United States)
William P. Melega, Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 8214:
Advanced Biomedical and Clinical Diagnostic Systems X
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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