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Proceedings Paper

Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
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Paper Abstract

We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

Paper Details

Date Published: 30 January 2012
PDF: 5 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82131Y (30 January 2012); doi: 10.1117/12.911587
Show Author Affiliations
Vivek J. Srinivasan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Harsha Radhakrishnan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
James Y. Jiang, Thorlabs Inc. (United States)
Scott Barry, Thorlabs Inc. (United States)
Alex E. Cable, Thorlabs Inc. (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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