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Proceedings Paper

Finding seeds for segmentation using statistical fusion
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Paper Abstract

Image labeling is an essential step for quantitative analysis of medical images. Many image labeling algorithms require seed identification in order to initialize segmentation algorithms such as region growing, graph cuts, and the random walker. Seeds are usually placed manually by human raters, which makes these algorithms semi-automatic and can be prohibitive for very large datasets. In this paper an automatic algorithm for placing seeds using multi-atlas registration and statistical fusion is proposed. Atlases containing the centers of mass of a collection of neuroanatomical objects are deformably registered in a training set to determine where these centers of mass go after labels transformed by registration. The biases of these transformations are determined and incorporated in a continuous form of Simultaneous Truth And Performance Level Estimation (STAPLE) fusion, thereby improving the estimates (on average) over a single registration strategy that does not incorporate bias or fusion. We evaluate this technique using real 3D brain MR image atlases and demonstrate its efficacy on correcting the data bias and reducing the fusion error.

Paper Details

Date Published: 14 February 2012
PDF: 7 pages
Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 831430 (14 February 2012); doi: 10.1117/12.911524
Show Author Affiliations
Fangxu Xing, The Johns Hopkins Univ. (United States)
Andrew J. Asman, Vanderbilt Univ. (United States)
Jerry L. Prince, The Johns Hopkins Univ. (United States)
Bennett A. Landman, Vanderbilt Univ. (United States)
The Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 8314:
Medical Imaging 2012: Image Processing
David R. Haynor; Sébastien Ourselin, Editor(s)

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