Share Email Print
cover

Proceedings Paper

Automatic corpus callosum segmentation using a deformable active Fourier contour model
Author(s): Clement Vachet; Benjamin Yvernault; Kshamta Bhatt; Rachel G. Smith; Guido Gerig; Heather Cody Hazlett; Martin Styner
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

The corpus callosum (CC) is a structure of interest in many neuroimaging studies of neuro-developmental pathology such as autism. It plays an integral role in relaying sensory, motor and cognitive information from homologous regions in both hemispheres. We have developed a framework that allows automatic segmentation of the corpus callosum and its lobar subdivisions. Our approach employs constrained elastic deformation of flexible Fourier contour model, and is an extension of Szekely's 2D Fourier descriptor based Active Shape Model. The shape and appearance model, derived from a large mixed population of 150+ subjects, is described with complex Fourier descriptors in a principal component shape space. Using MNI space aligned T1w MRI data, the CC segmentation is initialized on the mid-sagittal plane using the tissue segmentation. A multi-step optimization strategy, with two constrained steps and a final unconstrained step, is then applied. If needed, interactive segmentation can be performed via contour repulsion points. Lobar connectivity based parcellation of the corpus callosum can finally be computed via the use of a probabilistic CC subdivision model. Our analysis framework has been integrated in an open-source, end-to-end application called CCSeg both with a command line and Qt-based graphical user interface (available on NITRC). A study has been performed to quantify the reliability of the semi-automatic segmentation on a small pediatric dataset. Using 5 subjects randomly segmented 3 times by two experts, the intra-class correlation coefficient showed a superb reliability (0.99). CCSeg is currently applied to a large longitudinal pediatric study of brain development in autism.

Paper Details

Date Published: 13 April 2012
PDF: 7 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 831707 (13 April 2012); doi: 10.1117/12.911504
Show Author Affiliations
Clement Vachet, The Univ. of North Carolina at Chapel Hill (United States)
Benjamin Yvernault, The Univ. of North Carolina at Chapel Hill (United States)
Kshamta Bhatt, The Univ. of North Carolina at Chapel Hill (United States)
Rachel G. Smith, The Univ. of North Carolina at Chapel Hill (United States)
Carolina Institute for Developmental Disabilities, UNC-Chapel Hill (United States)
Guido Gerig, Scientific Computing and Imaging Institute, The Univ. of Utah (United States)
Heather Cody Hazlett, The Univ. of North Carolina at Chapel Hill (United States)
Carolina Institute for Developmental Disabilities, UNC-Chapel Hill (United States)
Martin Styner, The Univ. of North Carolina at Chapel Hill (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

© SPIE. Terms of Use
Back to Top