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Proceedings Paper

A framework of whole heart extracellular volume fraction estimation for low dose cardiac CT images
Author(s): Xinjian Chen; Ronald M. Summers; Marcelo Souto Nacif; Songtao Liu; David A. Bluemke; Jianhua Yao
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Paper Abstract

Cardiac magnetic resonance imaging (CMRI) has been well validated and allows quantification of myocardial fibrosis in comparison to overall mass of the myocardium. Unfortunately, CMRI is relatively expensive and is contraindicated in patients with intracardiac devices. Cardiac CT (CCT) is widely available and has been validated for detection of scar and myocardial stress/rest perfusion. In this paper, we sought to evaluate the potential of low dose CCT for the measurement of myocardial whole heart extracellular volume (ECV) fraction. A novel framework was proposed for CCT whole heart ECV estimation, which consists of three main steps. First, a shape constrained graph cut (GC) method was proposed for myocardium and blood pool segmentation for post-contrast image. Second, the symmetric Demons deformable registrations method was applied to register pre-contrast to post-contrast images. Finally, the whole heart ECV value was computed. The proposed method was tested on 7 clinical low dose CCT datasets with pre-contrast and post-contrast images. The preliminary results demonstrated the feasibility and efficiency of the proposed method.

Paper Details

Date Published: 14 February 2012
PDF: 7 pages
Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 831429 (14 February 2012); doi: 10.1117/12.911475
Show Author Affiliations
Xinjian Chen, National Institutes of Health (United States)
Ronald M. Summers, National Institutes of Health (United States)
Marcelo Souto Nacif, National Institutes of Health (United States)
Songtao Liu, National Institutes of Health (United States)
David A. Bluemke, National Institutes of Health (United States)
Jianhua Yao, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 8314:
Medical Imaging 2012: Image Processing
David R. Haynor; Sébastien Ourselin, Editor(s)

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