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Proceedings Paper

Multi-level tree analysis of pulmonary artery/vein trees in non-contrast CT images
Author(s): Zhiyun Gao; Randall W. Grout; Eric A. Hoffman; Punam K. Saha
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Paper Abstract

Diseases like pulmonary embolism and pulmonary hypertension are associated with vascular dystrophy. Identifying such pulmonary artery/vein (A/V) tree dystrophy in terms of quantitative measures via CT imaging significantly facilitates early detection of disease or a treatment monitoring process. A tree structure, consisting of nodes and connected arcs, linked to the volumetric representation allows multi-level geometric and volumetric analysis of A/V trees. Here, a new theory and method is presented to generate multi-level A/V tree representation of volumetric data and to compute quantitative measures of A/V tree geometry and topology at various tree hierarchies. The new method is primarily designed on arc skeleton computation followed by a tree construction based topologic and geometric analysis of the skeleton. The method starts with a volumetric A/V representation as input and generates its topologic and multi-level volumetric tree representations long with different multi-level morphometric measures. A new recursive merging and pruning algorithms are introduced to detect bad junctions and noisy branches often associated with digital geometric and topologic analysis. Also, a new notion of shortest axial path is introduced to improve the skeletal arc joining two junctions. The accuracy of the multi-level tree analysis algorithm has been evaluated using computer generated phantoms and pulmonary CT images of a pig vessel cast phantom while the reproducibility of method is evaluated using multi-user A/V separation of in vivo contrast-enhanced CT images of a pig lung at different respiratory volumes.

Paper Details

Date Published: 14 February 2012
PDF: 8 pages
Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 83142W (14 February 2012); doi: 10.1117/12.911471
Show Author Affiliations
Zhiyun Gao, The Univ. of Iowa (United States)
Randall W. Grout, The Univ. of Iowa (United States)
Eric A. Hoffman, The Univ. of Iowa (United States)
Punam K. Saha, The Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 8314:
Medical Imaging 2012: Image Processing
David R. Haynor; Sébastien Ourselin, Editor(s)

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