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Proceedings Paper

High-speed polarization sensitive optical coherence tomography for retinal diagnostics
Author(s): Biwei Yin; Bingqing Wang; Kalyanramu Vemishetty; Jim Nagle; Shuang Liu; Tianyi Wang; Henry G. Rylander; Thomas E. Milner
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Paper Abstract

We report design and construction of an FPGA-based high-speed swept-source polarization-sensitive optical coherence tomography (SS-PS-OCT) system for clinical retinal imaging. Clinical application of the SS-PS-OCT system is accurate measurement and display of thickness, phase retardation and birefringence maps of the retinal nerve fiber layer (RNFL) in human subjects for early detection of glaucoma. The FPGA-based SS-PS-OCT system provides three incident polarization states on the eye and uses a bulk-optic polarization sensitive balanced detection module to record two orthogonal interference fringe signals. Interference fringe signals and relative phase retardation between two orthogonal polarization states are used to obtain Stokes vectors of light returning from each RNFL depth. We implement a Levenberg-Marquardt algorithm on a Field Programmable Gate Array (FPGA) to compute accurate phase retardation and birefringence maps. For each retinal scan, a three-state Levenberg-Marquardt nonlinear algorithm is applied to 360 clusters each consisting of 100 A-scans to determine accurate maps of phase retardation and birefringence in less than 1 second after patient measurement allowing real-time clinical imaging-a speedup of more than 300 times over previous implementations. We report application of the FPGA-based SS-PS-OCT system for real-time clinical imaging of patients enrolled in a clinical study at the Eye Institute of Austin and Duke Eye Center.

Paper Details

Date Published: 30 January 2012
PDF: 6 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82132W (30 January 2012); doi: 10.1117/12.911447
Show Author Affiliations
Biwei Yin, The Univ. of Texas at Austin (United States)
Bingqing Wang, The Univ. of Texas at Austin (United States)
Kalyanramu Vemishetty, National Instruments Corp. (United States)
Jim Nagle, National Instruments Corp. (United States)
Shuang Liu, The Univ. of Texas at Austin (United States)
Tianyi Wang, The Univ. of Texas at Austin (United States)
Henry G. Rylander, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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